Propofol As Intralipid Therapy??
20% intravenous fat emulsion (IFE) may be useful to resuscitate severe cardiotoxicty due to fat-soluble drugs; the so-called lipid rescue. Propofol is a fat soluble anesthetic agent that is formulated and delivered in 3% IFE. If 20% IFE is not immediately available, can I use propofol as a substitute for 20% IFE?
What is Intravenous Lipid Emulsion?
How does it work?
What can it treat?
How do you give it?
Are there any adverse reactions?
What lab tests are altered?
Why do people think Propofol will work?
Have any studies been performed?
* Propofol in intralipid group had longer time to each adverse outcome than the other groups
What did I take away from this?
Propofol Infusion Syndrome (PRIS)
Diedrick, D, Brown D. Propofol Infusion Syndrome in the ICU. Journal of Intensive Care Medicine. 2011; 26 (2) 59-72. .
Rosen DJ, Nicoara A, Koshy N, Wedderburn RV. Too much of a good thing? Tracing the history of the propofol infusion syndrome. J Trauma. 2007;63(2):443-447.
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